Publications

MicroRNA-33 inhibits adaptive thermogenesis and adipose tissue beiging

Milessa Silva Afonso, Narendra Verma, Coen van Solingen, Yannick Cyr, Monika Sharma, Luce Perie, Emma M. Corr, Martin Schlegel, Lianne C. Shanley, Daniel Peled, Jenny Y. Yoo, Ann Marie Schmidt, Elisabetta Mueller, Kathryn J. Moore . Arterioscler Thromb Vasc Biol 2021 March 4.

Myocardial infarction accelerates breast cancer via innate immune reprogramming

G Koelwyn, A Newman, M Afonso, C van Solingen, E Corr, E J. Brown, K B. Albers, N Yamaguchi, D Narke, M Schlegel, M Sharma, L C. Shanley, T J. Barrett, K Rahman, V Mezzano, E A. Fisher, D S. Park, J D. Newman, D F. Quail, E R. Nelson, B J. Caan, L W. Jones & K J. Moore . Nat Med 2020 July 13.

Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression

M sharma, M Schlegel, M Afonso, E Brown, K Rahman, A Weinstock, B Sansbury, E Corr, C van Solingen, G Koelwyn, L Shanley, L Beckett, D Peled, J Lafaille, M Spite, P Loke, E Fisher, K Moore. Circ Res 2020 Apr 27.

Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

Sharma M, Boytard L, Hadi T, Koelwyn G, Simon R, Ouimet M, Seifert L, Spiro W, Yan B, Hutchison S, Fisher EA, Ramasamy R, Ramkhelawon B, Moore KJ. Sci Rep 2020 Mar 27;10(1):5555.

Regulation of stress granule formation by inflammation, vascular injury, and atherosclerosis

Herman AB, Silva Afonso M, Kelemen Se, Ray M, Vrakas, CN, Burke AC, Scalia RG, Moore K*, Autieri, MV*. Arterioscler Thromb Vasc Biol 2019;39:2014–2027.

Netrin-1 alters adipose tissue macrophage fate and function in obesity

Sharma M, Schlegel M, Brown EJ, Sansbury, BE, Weinstock A, Afonso MS, Corr EM, van Solingen C, Shanley LC, Peled D, Ramasamy R, Schmidt AM, Spite M, Fisher EA, Moore KJ. Immunometabolism 2019;1(2).

The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Hennessy EJ, van Solingen C, Scacalossi K, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab 2019;1:98-110.

microRNA-33 regulates macrophage autophagy in atherosclerosis

Ouimet M, Ediriweera H, Afonso MS, Ramkhelawon B, Singaravelu R, Liao X, Bandler RC, Rahman K, Fisher EA, Rayner KJ, Pezacki JP, Tabas I, Moore KJ. Arterioscler Thromb Vasc Biol 2017;37:1058-1067.

Mycobacterium tuberculosis induces the miR-33 locus to inhibit autophagy and reprogram host lipid metabolism

Ouimet M, Koster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA, Moore KJ. Nat Immunol 2016;17:677-686.

miRNA targeting of Oxysterol Binding Protein-like 6 (OSBPL6) regulates cholesterol trafficking and efflux

Ouimet M*, Hennessy EJ*, van Solingen C, Koelwyn GJ, Hussein MA, Ramkhelawon B, Rayner KJ, Temel RE, Perisic L, Hedin U, Maegdefessel L, Garabedian MJ, Holdt LM, Teupser D, Moore KJ. Arterioscler Thromb Vasc Biol 2016;36:942-951.

miR-33 regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest 2015;125:4334-4348.

miR-33 inhibition overcomes the deleterious effects of diabetes on atherosclerosis plaque regression in mice

Distel E, Barrett TJ, Chung K, Girgis NM, Parathath S, Essau CC, Murphy AJ, Moore KJ*, Fisher EA*. Circ Res 2014;115:759-769.

Netrin-1 promotes adipose tissue macrophage accumulation and insulin resistance in obesity

Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, Guo L, Oldebeken S, Feig JL, Fisher EA, Moore KJ. Arterioscler Thromb Vasc Biol 2013;33:1180-1188.

CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation

Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ. Nat Immunol 2013;14:812-820.

Hypoxia induces Netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival

Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, Guo L, Oldebeken S, Feig JL, Fisher EA, Moore KJ. Arterioscler Thromb Vasc Biol 2013;33:1180-1188.

Endothelial expression of guidance cues in vessel wall homeostasis: dysregulation under proatherosclerotic conditions

van Gils JM, Ramkhelawon B, Fernandes L, Stewart MC, Guo L, Seibert T, Menezes GB, Cara DC, Chow C, Kinane TB, Fisher EA, Balcells M, Alvarez-Leite J, Lacy-Hulbert A, Moore KJ. Arterioscler Thromb Vasc Biol 2013;33:911-919.

Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention

Wanschel A, Seibert T, Hewing B, Ramkhelawon B, Ray TD, van Gils JM, Rayner KJ, Feig JE, O’Brien ER, Fisher EA, Moore KJ. Arterioscler Thromb Vasc Biol 2013;33:886-893.

The neuroimmune guidance molecule Netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O’Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ. Nat Immunol 2012;13:136-143.

Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, Temel RE*, Moore KJ*. Nature 2011;478:404-407.

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Hernando C, Fisher EA, Moore KJ. J Clin Invest 2011;121:2921-2931.

miR-33 contributes to the regulation of cholesterol homeostasis

Rayner KJ*, Suarez Y*, Davalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ**, Fernandez-Hernando C**. Science 2010;328:1570-1573.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. Nature 2010;464:1357-1361

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Stewart CR* Stuart LM*, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ. Nat Immunol 2010;11:155-161.