Dr. Kathryn J. Moore named the American Heart Association’s 2021 Distinguished Scientist in Arteriosclerosis, Thrombosis and Vascular Biology
November 3, 2021
“Congratulations to Dr. Moore for her incredible research contributions that have helped forge new paths in our understanding of the biological origins of cardiovascular and cardiometabolic disease” – American Heart Association President Donald M. Lloyd-Jones, M.D., Sc.M., FAHA.
Kathryn J Moore, PhD elected to the National Academy of Sciences
April 26, 2021
The National Academy of Sciences announced the election of 120 members — 59 of whom are women, the most elected in a single year — and 30 international members in recognition of their distinguished and continuing achievements in original research.
For Another Year, Dr. Kathryn J. Moore Is Listed as One of the 2020 Most Influential Researchers
November 18, 2020
Congratulations to Dr. Moore who ranked in the top 1% of researchers based on citations for the year 2020. Dr. Moore is one of 26 researchers at NYU who made the list.
“In the race for knowledge, it is human capital that is fundamental and this list identifies and celebrates exceptional individual researchers at New York University who are having a great impact on the research community as measured by the rate at which their work is being cited by others” – David Pendlebury (Senior citation analyst at Clarivate’s Institute for Scientific Information).
The Scientist Magazine: Heart Attack Elevates Risk of Breast Cancer Recurrence
July 16, 2020
The Scientist magazine highlights findings from our recent publication in Nature Medicine. Our new paper shows how myocardial infarction accelerates breast cancer via innate immune reprogramming. In breast cancer survivors, a post cancer cardiovascular event is associated with a 60% increased risk in both cancer recurrence and cancer-specific mortality. Using mouse models of breast cancer, we showed that a heart attack accelerated tumor growth twofold. Transcriptomic and ATAC-seq profiling reveal a heart attack induced immunosuppressive phenotype that is epigenetically imprinted in bone marrow.
Latest Publication: LDL Receptor Pathway Regulation by miR-224 and miR-520d
May 26, 2020
We are delighted to showcase our work on the regulation of the low-density lipoprotein receptor pathway by conserved microRNAs in our latest publication in Frontiers in Cardiovascular Medicine. In the published article, we identified two microRNAs, miR-224, and miR-520d, which post-transcriptionally target gene networks regulating hepatic expression and function of the low-density lipoprotein receptor.
Dr. Milessa Afonso Listed as a Finalist for the ATVBWLC Junior Investigator Award
May 4, 2020
We are delighted to announce that Dr. Milessa Afonso of the Moore Lab has been listed as a finalist for ATVBWLC Junior investigator award for the Vascular Discovery Conference 2020. Dr. Afonso will present her work on how miR-33 inhibition promotes atherosclerotic plague regression.
Welcoming New Lab Members to the Team: Dr. Yannick Cyr and Fazli Bozal
March 10, 2020
We would like to welcome newest laboratory members Dr. Yannick Cyr and Fazli Bozal. Dr. Cyr completed his PhD in Molecular Biology at the University of Montreal and was trained at the Montreal Clinical Research Institute. As a post-doctoral fellow in the Moore Lab, he will focus on investigating the role of Netrin-1 in chronic inflammation within non-alcoholic steatohepatitis. Fazli Bozal is a current MD/PhD at NYU Grossman School of Medicine. He will join the Moore Lab as a graduate student and explore the metabolic regulation and reprogramming of the innate immune system in cardiovascular disease.
Building NYU Langone’s New Cardiovascular Research Center: An Interview with Dr. Kathryn Moore
February 20, 2020
NYULH Office of Communication and Marketing interviews Dr. Kathryn J. Moore on the newly constituted Cardiovascular Research Center (CVRC) and her roles as the new director. The interview covers Dr. Moore’s ambitions for the CVRC and her experiences working at NYU Langone Health.
Dr. Kathryn J. Moore Has Been Named the Inaugural Director of NYU’s New Cardiovascular Research Center
February 14, 2020
Congratulations to Dr. Kathryn Moore for her position as director of the newly constituted Cardiovascular Research Center (CVRC) at NYU Langone Health. Dr. Moore also serves as the Jean and David Blechman Professor of Cardiology and Professor of Cell Biology at NYU Grossman School of Medicine. She was recognized as an influential researcher at NYU in 2019 and was the recipient of NHLBI’s Outstanding Investigator Award in 2017. The CVRC’s mission is “to create a multi-disciplinary enterprise that supports and encourages research in basic, translational and clinical cardiovascular sciences to advance knowledge of cardiovascular diseases and translate these discoveries into innovative treatment therapies.”
Dr. Coen van Solingen Received a Career Development Award from the American Heart Association (2019-2021)
January 20, 2020
Dr. Coen van Solingen received a Career Development Award from the American Heart Association (2019-2021). The research plan awarded investigates how a newly discovered peptide, expressed only in humans, can promote inflammation that drives heart disease. We have named this small peptide Inflammation Modulating Peptide (IMP). Interestingly, IMP was found in the parts of the DNA that we used to call ‘junk DNA’. IMP is detected in high levels in the immune cells that are present in the developing atherosclerotic plaque. Our research suggests that IMP stimulates the inflammatory response within these cells, and we are working to understand how it does this, with the ultimate goal of designing a therapy to block it.
Dr. Kathryn Moore Makes List of Most Influential Researchers
December 1, 2019
Dr. Kathryn J. Moore is recognized as an influential researcher, defined by the article as “world-class researchers selected for their significant influence in their fields, which at NYU, range from genomics to economics and cardiology to neuroscience. The scientists and social scientists chosen from around the world have published multiple papers that rank in the top 1 percent by citations in their field over the past decade (2008-2018), according to Web of Science.”
Dr. Kathryn J. Moore Awarded the 2018 Mentor of Women Award from the ATVB
June 1, 2018
Congratulations to Dr. Kathryn Moore who recently received the 2018 Mentor of Women Award from the ATVB Women’s Leadership Committee. The award is presented annually to a member of the ATVB Council who has shown exceptional support of the careers of women in the fields of atherosclerosis, thrombosis, and vascular biology on an individual and global basis through mentoring and advocacy.
New Advances in Cardiac and Vascular Research
January 15, 2018
Dr. Kathryn J. Moore is acknowledged as one of three researchers who have been jointly granted $12 million, over the course of 5 years, from the National Heart, Lung and Blood Institute (NHLBI) of the NIH. The grant will support research exploring macrophage role in obesity, diabetes and atherosclerosis. The article further highlights Dr. Moore’s recent achievement as recipient of NHLBI’s Outstanding Investigator Award. This award grants Dr. Moore the opportunity to take larger research risks, which may need longer timeframes.
Tuberculosis Bacteria Build ‘Edible’ Havens in Immune Cells
April 18, 2016
This article by NYULH Press Releases presents newly published information from the Moore Lab regarding the role of microRNA-33 in tuberculosis progression and how this research increases the scientific and health community’s understanding of the disease’s mechanisms. Dr. Moore comments on future directions for miR-33 research and potential treatment designs for tuberculosis.
Blocking Key Signaling Chemical in the Immune System Stalls Chronic Inflammation and Insulin Resistance Tied to Obesity
March 3, 2014
Newswise reports a critical discovery from the Kathryn J. Moore Lab, regarding the role of Netrin-1 in chronic inflammation and insulin resistance associated with obesity. The article highlights key findings, methodology and future directions, pulling from the Moore Lab’s publication in the March 2014 issue of Nature Medicine and subsequent interviews.
New Way Discovered to Block Inflammation
June 1, 2013
ScienceDaily covers a new discovery from the Moore Lab, which illuminates a novel “mechanism that triggers chronic inflammation in Alzheimer’s, atherosclerosis and type-2 diabetes” than previously suggested by earlier studies. Researchers previously believed cholesterol crystals and plaques accumulated outside the cell and inflammation was induced as macrophages attempted to clear the debris. Instead, the Moore Lab demonstrates that a receptor present on macrophages, CD36, binds and pulls soluble cholesterol and protein matter into the cell. The debris is transformed into insoluble crystals and amyloids, damaging the macrophage and triggering interleukin-1β, a cytokine associated with chronic inflammatory responses.